π¬ GBM Clinical Trials
Active trials, completed results, and how to find them
β
Completed Trials β Key Results
Metabolic / Dietary
| Trial | Intervention | Results | Link |
|---|
| Ketogenic Diet Phase 1 |
Keto + standard treatment |
Safe, feasible |
Nature 2025 |
| Ketogenic Metabolic Therapy |
Strict keto protocol |
Long-term survivors |
Frontiers 2024 |
Repurposed Drugs
| Trial | Intervention | Results | Link |
|---|
| Mebendazole Phase 1 |
MBZ + TMZ (24 patients) |
Safe at 200mg/day |
NCT01729260 |
| Mebendazole + TMZ |
Combined therapy |
Well tolerated |
Neuro-Oncol 2021 |
Natural Compounds
| Trial | Intervention | Results | Link |
|---|
| Integrative Oncology |
Curcumin + Boswellia + Polydatin (72 pts) |
Improved survival |
MDPI 2025 |
| Boswellia for Edema |
Brain swelling reduction |
Reduced steroid need |
Cancer 2011 |
π Active/Recruiting Trials
Immunotherapy (Most Promising)
| Trial ID | Intervention | Phase | Status |
|---|
| NCT02017717 |
DCVax-L (dendritic cell vaccine) |
Phase 3 |
Active |
| NCT04201873 |
CAR-T EGFRvIII |
Phase 1 |
Recruiting |
| NCT05283486 |
CAR-T IL13RΞ±2 |
Phase 1 |
Recruiting |
| NCT03347097 |
Nivolumab + Ipilimumab |
Phase 2/3 |
Active |
Viral Therapy (Oncolytic Viruses)
| Trial ID | Intervention | Phase | Status |
|---|
| NCT02986178 |
PVS-RIPO (polio virus) β Duke |
Phase 2 |
Active |
| NCT02197169 |
DNX-2401 (adenovirus) |
Phase 2 |
Active |
| Japan |
G47β (HSV virus) |
β |
APPROVED β |
Repurposed Drugs (Active)
| Trial ID | Intervention | Phase | Status |
|---|
| NCT02644291 |
Mebendazole (recurrent GBM) |
Phase 1 |
Active |
| NCT04195139 |
Disulfiram + copper |
Phase 1/2 |
Recruiting |
| NCT01894633 |
Metformin |
Phase 1/2 |
Active |
β οΈ Research Gaps β No Trials
Major Problem: These compounds have preclinical evidence but NO active GBM clinical trials:
- Ivermectin β Strong cell + animal studies, no human GBM trial
- Fenbendazole β Animal studies, veterinary drug
- Berberine β Animal + cell studies, natural compound
- High-dose Curcumin β Preclinical only for GBM-specific
- Honokiol β Cell studies, crosses BBB
Why? Compounds without patent potential don't attract pharmaceutical funding. This is why patient advocacy and independent research matter.
π Major GBM Research Centers
United States
- Duke University β PVS-RIPO polio virus, immunotherapy leader
- MD Anderson Cancer Center β Multiple trials
- UCSF β CAR-T cell therapy
- Johns Hopkins β Mebendazole, metabolic approaches
- Mayo Clinic β Various novel trials
Europe
- University Hospital Zurich β Switzerland
- Gustave Roussy β France
- CharitΓ© Berlin β Germany
Asia
- University of Tokyo β G47β viral therapy (first approved!)
π How to Join a Trial
- Search β Use links above to find trials for your tumor type
- Check eligibility β Each trial has specific criteria (tumor status, prior treatments, etc.)
- Contact β Find contact info on trial page, or ask your oncologist to refer you
- Understand risks β Ask about placebo arms, side effects, travel requirements
- Advocate β If denied, ask why and whether exceptions can be made