Repurposed antiparasitic — Johns Hopkins Phase 1 completed
| Property | Detail |
|---|---|
| Type | Antiparasitic drug (repurposed) |
| Evidence | ✓ Phase 1 Trial ✓ Crosses BBB |
| Discovery | Accidental (mice with pinworms) |
Johns Hopkins researchers treating lab mice for pinworms noticed tumors stopped growing. This led to formal research on mebendazole for brain cancer.
Mebendazole comes in different crystal forms. Polymorph C has best brain penetration. Most OTC versions are Polymorph A (less effective).
| Source | Dose |
|---|---|
| Phase 1 trial | 200 mg/day with fatty meal |
| Fenbendazole alt. | 222 mg, 3 on/4 off |