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🌸 Honokiol (Magnolia)

Excellent BBB penetration + helps anxiety/sleep

Property	Detail
Source	Magnolia officinalis bark
Key Feature	✓ Excellent BBB Penetration
Bonus	Anxiolytic, sleep support

Why BBB Matters

Most compounds can't reach brain tumors. Honokiol crosses the blood-brain barrier efficiently — critical for GBM treatment.

Effects

• Induces apoptosis in GBM cells
• Inhibits EGFR pathway
• Targets GBM stem cells

Additional Benefits

• Reduces anxiety without sedation
• Improves sleep
• Neuroprotective

Dosage

Magnolia bark extract: 200-400 mg/day, evening

Products

• NOW Magnolia Extract
• Swanson Magnolia Bark

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