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🫚 Berberine

Natural compound — crosses BBB, increased survival in animal studies

Property	Detail
Source	Barberry, goldenseal
Evidence	✓ Animal Studies ✓ Crosses BBB
Traditional Use	Chinese medicine

Key Findings

• Reduced tumor volume in mouse models
• Increased survival
• Confirmed brain penetration
• Downregulates mTOR pathway

Dosage

Use	Dose
Standard	500 mg 2-3x/day
Start low	500 mg/day (GI issues common)

Products

• Thorne Berberine-500
• NOW Berberine

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